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Women also were contacted after they delivered and asked about pregnancy outcome. The relation between periconceptional vaginal spermicide use and sex ratio at birth, birthweight, and the frequency of congenital anomalies was examined in a cohort of 2, New York City obstetric patients, of whom 5. There was a slight inverse association between the length of postconceptional use and birthweight among female infants but not among male infants. The size of the effect and its selectivity by sex suggest a chance finding. The women participated in an interview prior to delivery, usually during their 2nd trimester of pregnancy. Periconceptional spermicide use was not associated with any important variation in the expected sex ratio at birth, nor with major or minor congenital anomalies. Specific questions were asked about contraceptive use immediately before the last menstrual period, at the time of conception 14 days after the last menstrual periodand after conception.

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Among women who had used spermicides after conception, the ratio did not vary systematically with the number of exposure.

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A cohort of New York City obstetric patients were the subjects in a study designed to examine the relation between periconceptional vaginal spermicide use and sex ratio at birth, birthweight, and the frequency of congenital anomalies. The rate of minor anomalies was slightly increased among periconceptional users but confidence limits aroung the relative risk were wide. There was a slight decrease in birthweight among female infants with increasing duration of postconceptional spermicide use; an estimated 7. The 4 anomalies observice in the offspring of women who had used spermicides around the time of conception were polydactyly, hemangioma, skin tags, and malformed ears. There was a slight inverse association between the length of postconceptional use and birthweight among female infants but not among male infants. Among women who had used spermicides after conception, the ratio did not vary systematically with the number of exposure.

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